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Active Research

Speciality Short Title Full Title PI  NIHR Link (Where available)
Anaesthesia Epoch Enhanced Peri-Operative Care for High-risk patients (EPOCH) Trial: A stepped wedge randomised cluster trial of a quality improvement intervention for patients undergoing emergency laparotomy Dr James Limb Link
- The POPULAR Study POstanaesthesia PULmonary complications After use of muscle Relaxants in Europe Dr James Limb Link
Cancer ESPAC 4 EUROPEAN STUDY GROUP FOR PANCREATIC CANCER - TRIAL 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers. Dr Fareeda Coxon Link
- GO2 Alternative chemotherapy for frail or elderly patients with advanced gastric or oesophageal cancer Dr Nick Wadd Link
- PERSEPHONE Duration of Trastuzumab with chemotherapy in women with early stage breast cancer: six months versus twelve Dr Wendy Taylor Link
- SELECT-d select-d: Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism Dr Natalie Cummings Link
- Sofea Study of Faslodex with or without concomitant Arimidex vs Exemestane following progression on non-steroidal Aromatase inhibitors Dr Wendy Taylor Link
- Stampede Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy Dr John Hardman Link
- RESPECT-Meso A multicentre non-blinded randomised controlled trial to assess the impact of Regular Early SPEcialist symptom Control Treatment on quality of life in malignant Mesothelioma " - RESPECT-Meso" Dr Colette Hawkins Link
- MANTA A Randomized Phase II Study of Fulvestrant in Combination with the dual mTOR Inhibitor AZD2014 or Everolimus or Fulvestrant alone in Estrogen ReceptorPositive Advanced or Metastatic Breast Cancer Dr Wendy Taylor Link
- CAVA Cancer and Venous Access (CAVA) - A randomised controlled trial with associated qualitative research of venous access devices for the delivery of long-term chemotherapy Dr Julie Cox Link
Cardiovascular REVEAL REVEAL: Randomized EValuation of the Effects of Anacetrapib through Lipid-modification. A large-scale, randomized placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease Dr Jerry Murphy Link
- EMMACE-4 Evaluation of the Methods and Management of Acute Coronary Events-4: Investigating Variation in Hospital Acute Coronary Syndrome Outcomes Dr Mohamed B A El-Harari Link
- LiveLife oLder HF patients Initiated on iVabradinE in the UK: quaLIty of liFE​ Dr Mohamed B A El-Harari Link
- ROSE Rivaroxaban Observational Safety Evaluation (ROSE) Study Dr Mohamed B A El-Harari Link
- GLORIA - AF GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation  Dr Mohamed B A El-Harari Link
Children PREDNOS Long-term tapering verses standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: national multicentre randomised double blind trial Dr John Furness Link
- PREDNOS 2 Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study. Dr Asha Nair Link
Critical Care PROVENT Practice of ventilation in critically ill patients without ARDS (PROVENT). An international observational study. Dr James Limb Link
DenDrON The AMPLE study Amyloid imaging for phenotyping Lewy body dementia  Dr Mark Carson Link
- Parkinsons Pain The Parkinson's Pain Study Dr Mark Carson Link
- PD GEN PD GENetics: Parkinson's Disease DNA Bank Dr Mark Carson Link
- PRoBaND PRoBaND: Parkinson's Repository of Biosamples and Network Datasets: Prospective observational study of Parkinson's disease with repeat clinical assessment and biobanking of blood samples. Dr Mark Carson Link
- PROBAND ADD-on Assessment of respiratory function in a representative cohort of patients with early Idiopathic Parkinson's disease or diagnosed below 50 years of age. Tracking Parkinson's (PRoBaND) add on study.   Dr Mark Carson Link
- PD MED PD MED: A large randomised assessment of the relative cost-effectiveness of different classes of drugs for Parkinson's Disease  Dr Mark Carson Link
Dermatology SIGNATURE Secukinumab in patients with moderate to severe active, chronic plaque psoriasis who have failed on TNFα antagonists: a clinical trial evaluating treatment results. Dr Shyamal Wahie Link
- Long-term effect of NBUVB on Atopic Eczema  Investigating the course of atopic eczema up to 1 year following completion of Narrowband UVB (NBUVB) phototherapy Dr Shyamal Wahie Link
- AWARE AWARE: A Worldwide
Antihistamine Refractory
Chronic Urticaria Patient Evaluation
Dr Shyamal Wahie
- Genetics in Acne A case-control study for genotype phenotype associations in moderate to severe acne vulgaris Dr Shyamal Wahie Link
Diabetes CAROLINA A multicentre, international, randomised, parallel group, double blind study to evaluate Cardiovascular safety of linagliptin versus glimepiride in patients with type 2 diabetes mellitus at high cardiovascular risk. Dr Kamal Abouglila Link
- REMOVAL REducing with MetfOrmin Vascular Adverse Lesions in T1DM (The Removal study). Dr Kamal Abouglila Link
- INTENSE Real World Effectiveness Of Lixisenatide And Other Intensification Therapy In The Management Of Type 2 Diabetic Patients Uncontrolled With Basal Insulin Dr Kamal Abouglila/Praveen Partha Link
- The CREDENCE Study A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects With Type 2 Diabetes Mellitus and Diabetic Nephropathy Dr Kamal Abouglila/Praveen Partha Link
Gastroenterology COMPOSE III A Randomized Double-blind, Placebo-controlled,Parallel-group, Multicenter, Phase 3 Study to Evaluate the Long-term Safety of Naldemedine for the Treatment of Opioid-induced Constipation in Subjects with Nonmalignant Chronic Pain Receiving Opioid Therapy Dr Yan Yiannakou Link
- ECHO 3 A Multicenter, Open-label, Safety and Tolerability Extension Trial of 5 mg and 10 mg Elobixibat Daily in the Treatment of Chronic Idiopathic Constipation Dr Yan Yiannakou Link
- RAPID A randomised placebo controlled trial of follow on Rifaximin for the prevention of relapse of Clostridium difficile associated diarrhoea Dr Anjan Dhar Link
- seAFOod A randomised controlled trial of eicosapentaenoic acid (EPA) and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) polyp prevention trial. Clare Westwood Link
- TOPPIC Randomised controlled trial of 6-Mercaptopurine versus placebo to prevent recurrence of Crohn's disease following surgical resection Dr Anjan Dhar Link
- CHOPIN Chemoprevention of premalignant intestinal neoplasia (ChOPIN) incorporating inherited predisposition of neoplasia (IPOD) analysis of genomic DNA from AspECT and BOSS clinical trials. It also incorporates patients undergoing genomic assessment independent of the AspECT and BOSS trials. Dr Anjan Dhar Link
- PRED 4 Predicting serious drug side effects in gastroenterology Dr Anjan Dhar Link
- PANTS Investigation of the clinical, serological and genetic factors that determine primary non-response, loss of response and adverse drug reactions to Anti-TNF drugs in patients with active luminal Crohn's Disease Dr Anjan Dhar Link
- TILTS Tined lead test stimulation to predict long-term benefit from sacral nerve stimulation in patients with chronic constipation (TiLTS-cc). Dr Yan Yiannakou Link
- ETHOS A pragmatic multicentre randomised controlled trial comparing stapled haemorrhoidopexy to traditional excisional surgery for haemorrhoidal disease Dr Venkatesh Shanmugam  Link
Haematology CELGENE

A non-interventional post authorisation registry of patients treated with pomalidomide for relapsed and refractory multiple myeloma who have received at least two prior treatment regimens, including both lenalidomide and bortezomib, and have demonstrated disease progression on the last therapy

Dr Mohsen Mamoud Link
Hepatology PBC Genetics Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis Dr Sushma Saksena Link
- PSC Genetics A UK Collaborative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC) Dr Sushma Saksena Link
- RITPBC Rituximab for the Treatment of Fatigue in Primary Biliary Cirrhosis (PBC) Dr Sushma Saksena Link
- DILIGEN Pharmacogenetics of drug-induced liver injury Dr Sushma Saksena Link
Injuries and Emergencies HALT-IT Tranexamic Acid for the Treatment of Gastrointestinal Haemorrhage: An International Randomised, Double Blind Placebo Controlled Trial Dr Ola Afolabi Link
- CRASH 3 Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: An International, Randomised, Double Blind, Placebo Controlled Trial. Dr Ola Afolabi Link
Musculoskeletal SWITCH SWITCH: Randomised-controlled trial of switching to alternative tumour-necrosis factor (TNF)-blocking drugs or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-blocking drug Dr Dayavathi Ashok Link
- ACT-TAPER Randomised, Phase IV, placebo-controlled, comparative study to evaluate the efficacy and safety of tapering methotrexate (MTX) dosage versus maintaining the dosage in patients with severe active rheumatoid arthritis (RA) who have demonstrated an inadequate response to prior conventional disease-modifying anti-rheumatic drugs (DMARDs) treatment and have initiated RoActemra® (tocilizumab, TCZ) in combination with MTX. Dr Matt Bridges Link
- BRAGGSS Investigation of factors influencing arthritis and response to therapy with biologic drugs Dr Matt Bridges Link
- BSRBR AS British Society for Rheumatology Biologics Registers - Ankylosing Spondylitis Dr Sarah Hailwood Link
- BSRBR Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis Dr Matt Bridges Link
- TACERA The TACERA Study: A Longitudinal Observational Study of Patients with Early Rheumatoid Arthritis Dr Namita Kumar Link
- FRACTURE FREE The Fracture Free Study: A Prospective Cohort of Patients Presenting with a Fragility Fracture Examining the Predictors of Re-fracture Mr Andrew Jennings Link
Primary Care AFFIRM Study to determine the safety and effectiveness of flutiform®(Affirm) Dr John Furness Link
Reproductive Health and Childbirth Dr Seema Sen Link
- TABLET A Randomised Controlled Trial of the Efficacy and Mechanism of Levothyroxine Treatment on Pregnancy and Neonatal Outcomes in Women with Thyroid Antibodies. (TABLET: Thyroid AntiBodies and LEvoThyroxine Study) Dr Seema Sen Link
- DAPPA Spot protein creatinine ratio (SPCr) and spot albumin creatinine ratio (SACr) in the assessment of pre-eclampsia: A diagnostic accuracy study with decision analytic model based economic evaluation and acceptability analysis Dr Seema Sen Link
- FACT Effect of folic acid supplementation in pregnancy on preeclampsia -Folic Acid Clinical Trial (FACT) A randomized, double-blind, placebo-controlled, Phase III, international multi-centre study of 4.0 mg of Folic Acid supplementation in pregnancy for the prevention of preeclampsia Dr Seema Sen Link
- MINESS The Midlands and North of England Stillbirth Study MiNESS Dr Seema Sen Link
- EMPIRE AntiEpileptic drug Monitoring in PREgnancy: An evaluation of effectiveness, cost-effectiveness and acceptability of dose monitoring strategies Dr Tadala Saukila Link
- Thyroid Antibody Prevalence Study Thyroid Antibody Prevalence Study: A prospective observational study investigating the prevalence of thyroid peroxidase antibodies in women of reproductive age  Dr Seema Sen Link
Respiratory Disorders Dr Alwyn Foden Link
- RESPECT-Meso A multicentre non-blinded randomised controlled trial to assess the impact of Regular Early SPEcialist symptom Control Treatment on quality of life in malignant Mesothelioma " - RESPECT-Meso" Dr Colette Hawkins Link
- PASIC Pharmacogenetics of Adrenal Suppression with Inhaled corticosteroids in adults with Chronic Obstructive Pulmonary Disease Dr Neil Munroe Link
Stroke ENCHANTED Enhanced Control of Hypertension and Thrombolysis Stroke Study Dr Sofia Dima Link
- FOCUS A Multicentre randomised trial to establish the effect (s) of routine administration of Fluoxetine in patients with a recent stroke: start-up phase Dr Mahesh Dhakal Link
- RESTART REstart or STop Antithrombotics Randomised Trial Dr Sofia Dima Link
- TARDIS Safety and efficacy of intensive versus guideline antiplatelet therapy in high risk patients with recent ischaemic stroke or transient ischaemic attack: a randomised controlled trial Dr David Bruce Link
- TICH 2 Tranexamic acid for IntraCerebral Haemorrhage Dr Sofia Dima Link
Surgery VUE Vault or Uterine prolapse surgery Evaluation. Two parallel randomised controlled trials of surgical options for upper compartment (vauilt or uterine) pelvic organ prolapse. Mr Rob Wood Link
- BASIL 2 Multi-centre randomised controlled trial to compare the clinical and cost-effectiveness of a 'vein bypass first' with a 'best endovascular first' revascularisation strategy for severe limb ischaemia due to infra-popliteal arterial disease: Bypass vs. Angioplasty in Severe Ischaemia of the Leg.  Mr Philip Davey Link

'I have to compliment everyone on their pleasant persona and their expertise and knowledge. By the end of the 5 days, I did not feel as though I had been in a hospital ward and was very relaxed.'

Patient, Ward 16 Orthopaedics, University Hospital of North Durham